| CAS
NO. |
547-32-0
(Sodium); 68-35-9 (base) |
|
| EINECS
NO. |
208-919-0;
200-685-8 |
| FORMULA |
C10H9N4NaO2S |
| MOL
WT. |
272.26 |
|
H.S.
CODE
|
|
|
TOXICITY
|
|
| SYNONYMS |
Sodium,
(N(1)-2-pyrimidinylsulfanilamido)-; |
| 2-Sulfanilamidopyrimidine sodium salt; Benzenesulfonamide,
4-amino-N-2-pyrimidinyl-, monosodium salt; Monosodium
2-sulfanilamidopyrimidine; N(1)-2-Pyrimidinylsulfanilamide monosodium salt;
N1-2-Pyrimidinylsulfanilamide monosodium salt; Solfadiazina sodica; Soluble sulfadiazine;
Soludiazine; Sulfadiazin-natrium; Sulfadiazina sodica; Sulfadiazine sodique;
Sulfadiazinum natricum; Sulfanilamide, Sulphadiazine; Suthogen;
Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, monosodium salt;
2-Sulfanilamidopyrimidin; 2-Sulfanilamidopyrimidine; Adiazin; Adiazine;
Cremodiazine; Cremotres; Debenal; Deltazina; Diazin; Diazolone; Diazovit;
Diazyl; Eskadiazine; Liquadiazine; Metha-Meridiazine; Microsulfon;
N(1)-2-Pyrimidinylsulfanilamide; Neazine; Neotrizine; Palatrize; Sodium sulfapyrimidine; |
| DERIVATION |
|
|
CLASSIFICATION
|
|
|
PHYSICAL AND CHEMICAL PROPERTIES
|
| PHYSICAL
STATE |
white
to off-white crystalline powder |
| MELTING POINT |
|
| BOILING
POINT |
|
| SPECIFIC GRAVITY |
|
| SOLUBILITY
IN WATER |
Soluble |
| pH |
|
| VAPOR DENSITY |
|
|
REFRACTIVE
INDEX
|
|
|
NFPA
RATINGS
|
|
|
AUTOIGNITION
|
|
|
FLASH
POINT
|
|
| STABILITY |
Stable under normal conditions. |
|
GENERAL
DESCRIPTION & APPLICATIONS
|
|
Sulfadiazine
is a short-acting sulfonamide
antibiotic
used
in the treatment of infections due to susceptible organisms, including nocardiosis,
toxoplasmosis,
otitis
media caused by susceptible strains of Haemophilus
influenzae, streptococci,
and pneumococci,
and falciparum
malaria caused by chloroquine-resistant
plasmodia. It eliminates bacteria by stopping the production of folic acid inside the bacterial cell, and is
commonly used to treat urinary tract infections. It is frequently used in combination with other sulfonamides
and pyrimethamine to treat
toxoplasmosis in patients with acquired immunodeficiency syndrome and in
newborns with congenital infections. Silver sulfadiazine (the silver derivative of sulfadiazine)
is a topical antibacterial against many gram-positive and gram-negative
organisms, as well as being effective against yeasts; used as a topical antiinfective
for the prevention and treatment of second- and
third-degree burns. The sodium salt of sulfadiazine has the same actions with
the base and is administered intravenously.
|
| SALES
SPECIFICATION |
|
APPEARANCE
|
white
to off-white crystalline powder |
|
ASSAY
|
99.0%
min
|
|
ALKALINITY |
9.5 - 10.5 |
|
COLOR OF SOLUTION |
Y3 max |
|
SELENIUM |
30ppm max |
|
LOSS ON DRYING |
0.5%
max |
|
RELATED MATTERS |
0.5%
max |
| TRANSPORTATION |
| PACKING |
|
| HAZARD CLASS |
|
| UN
NO. |
|
| OTHER
INFORMATION |
|
|